Oxidative Stress and Neurodegenerative Disorders

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Oxidative Stress and Neurodegenerative Disorders

By Qureshi, G. Ali; Parvez, S. Hasan

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Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.

* Contains the latest information on the subject of neurodegenerative disorders
* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Subject: Allied Health & Medical -> Medical -> Toxicology

Oxidative Stress and Neurodegenerative Disorders
Publisher: Elsevier S & T 03/2007
Imprint: Elsevier Science
Language: English
Length: 794 pages

ISBN 10: 0444528091
ISBN 13: 9780444528094
Print ISBN: 9780444528094

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