PNH and the GPI-Linked Proteins

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PNH and the GPI-Linked Proteins

By Young, Neal S.; Moss, Joel

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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients.
Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins.
This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins.

Key Features
* Outlines the chemical features of PNH
* Explains the mechanism of hemolysis
* Includes work on the biochemistry of glycophosphoinositol anchors
* Contains descriptions of the chemistry and biophysics of GPI-anchored proteins

Subject: Allied Health & Medical -> Medical -> Biochemistry

PNH and the GPI-Linked Proteins
Publisher: Elsevier S & T 04/2000
Imprint: Academic Press
Language: English
Length: 279 pages

ISBN 10: 0127729402
ISBN 13: 9780127729404
Print ISBN: 9780127729404

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