The Somatotrophic Axis in Brain Function

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The Somatotrophic Axis in Brain Function

By Nyberg, Fred

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The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.

This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.

Contents are well balanced and cover a variety of relevant topics from basic to clinical research

International selection of authors, with a good representation of the research on growth hormones

A timely publication which will be useful to scientists in both basic and clinical research

Subject: Allied Health & Medical -> Medical -> Neuroscience

The Somatotrophic Axis in Brain Function
Publisher: Elsevier S & T 12/2005
Imprint: Academic Press
Language: English
Length: 384 pages

ISBN 10: 0120884844
ISBN 13: 9780120884841
Print ISBN: 9780120884841

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