Write about the effect of the drug Pioglitazone (Actos) on megalin/ cubilin and cytokines (in regulation of megalin/ cubilin).

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Peroxisome proliferator activated receptor (PPAR) activators are considered as promising drugs for the treatment of T2DM. Thiazolidinediones (TZDs) are well known PPAR activators such as pioglitazone (Actos) and rosiglitazone (Avandia) [1]. TZDs like pioglitazone induced PPAR activation lead to an increased PPAR-gamma mediated mRNA and protein levels involved in lipid and glucose metabolism by increasing insulin sensitivity. Pioglitazone ameliorates insulin resistance by utilizing circulating insulin in an...

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