You are given a new drug to test for which there is some suspicion of hematotoxicity. Describe the testing program you would use to determine whether the chemical is, in fact, hematotoxic. Provide a rationale for the overall testing scheme and the specific recommended tests

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Hematotoxicity may caused by several chemicals or agents which lead to variety of blood disorders such as anemia, aplastic anemia, agranulocytosis, thrombocytopenia, neutropenia, myelodysplasticlmyeloproliferative neoplasms, myeloproliferative neoplasms, myelodysplastic syndromes etc. The agents which cause the hematotoxicity are referred as hematotoxins.

To determine whether a new drug have or have not hematotoxic property, we can employ some quantitative and qualitative tests or assays i.e. complete blood count, peripheral blood smear, bone marrow aspirate and biopsy, flow cytometry / immunophenotyping, chromosome analysis, and colony-forming units assay.

The rationale behind these tests or assays is to know the irregularities of balance between all blood cells under pathogenic condition than normal condition. In normal condition the balance between blood cell production and degradation is regulated by variety of growth factors, and cytokines. The in vitro hematotoxicology could play an important role in new drug discovery through prediction of the maximum tolerance level of drug exposure for hematopoietic cells in human....
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