1) When the immune system of a person with Tuberculosis is trying to fight off the bacteria, chemicals are produced from particular lymphocytes. These chemicals raise the core body temperature and the core body temperature ‘thermostat’ setting is also changed. State which part of the brain would be affected?

2) During exercise the heart rate increases. After exercise, there is a recovery period where the heart rate is returned to normal. State which part of the brain would be damaged if this could not occur and explain your answer.

3) Demyelination is the loss of myelin from neurones that are normally myelinated. Multiple sclerosis is a disease in which demyelination occurs in neurones involved in coordinating muscle movement.

Using your knowledge of nerve impulse generation and propagation, explain how nerve impulse generation and propagation would be affected in people who have multiple sclerosis. The explanation needs to be in the form of a step by step sequence of annotated drawings. This could be in the form of an annotated cartoon/picture strip.

Compare this to nerve impulse generation and propagation in an individual who does not have multiple sclerosis.

4) a) Depression is a condition in which sufferers may feel low mood, lack of motivation and sleep. It is caused by a lack of serotonin in the synaptic cleft of neurone pathways. Serotonin is a neurotransmitter.

Describe how serotonin acts as a neurotransmitter. Using your understanding of synaptic transmission, explain how communication between neurones in serotonin pathways of the brain would be affected in someone with depression.

b) Doctors use tubocurarine drug as an anaesthetic as it temporarily paralyses muscles. It blocks receptors at neuromuscular junctions. Why does this lead to paralysis?

1) When the immune system of a person with Tuberculosis is trying t...