Subject Biology Cellular Biology

Question

Discuss the effects of histone modification and DNA modification on transcription.
Describe ways in which marks can activate and repress transcription for both types of modification.
For all modifications, describe any known mechanisms of action.

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Discuss the effects of histone modification and DNA modification on Transcription.
Answer:
In the eukaryotic cells, DNA in the nuclei wraps in the region of the octamer of histone protein that is known as nucleosome, i.e. ‘beads on a string,' that forms the basic element of chromatin. The structure of chromatin can be altered by various post-translational modifications of histone proteins residing on the N-terminal tail residues. These modifications include:
Acetylation: The lysine residue neutralizes...

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