QuestionQuestion

explore the effects of changes gene expression affect T lymphocyte activation.
We will explore two specific questions:

1) How do the changes in gene expression early in T lymphocyte activation lead to the prolonged activation signal need for the proper immune response

2) What are the relative contributions of gene expression heterogeneity and stimulus strength/pattern to activation of the transcription factors involved in T cell differentiation.

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PROPOSAL

To study the effects of changes in gene expression affect T lymphocyte activation

Introduction -

The immune system is divided into the innate and adaptive immune system. The innate immune cells like neutrophils, natural killer cells, dendritic cells initially help in infection containment. They also direct the functioning of adaptive immune cells. In response to the inflammation from the innate response, the adaptive immune cells (T cells and B cells) proliferate and differentiate into cells with functions to eliminate the pathogen. T cells play...

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