Question
Transcribed Text
È
o
0.05
0.1
0.15
0.2
Z(A)
-3.0
-2.0
-1
0.3
Z(B)
0.1
0.2
10
0.6
0.3
Z(C)
4.0
3.0
2.0
0.8
0.2
Z(D)
-00
2.0
4.0
4.2
2.5
The table above gives the Zscores for four different marker loci (A. B, Cand D) with respect to
possible linkage to a monogenic, fully penetrant trait.
a. Which markers is/are significantly linked to the trait allele anywhere within 0sus0.2?
(1pt)
b. Which marker appears to be closest (fewest cM away) to the trait allele?
(1pt)
c. Which markers, if any, definitelyi is/are NOT linked to the trait allele specifically at U=0?
(1pt)
(they may be linked at other values of U)
d. For which markers, if any, can we make no definite conclusion about linkage?
(1pt)
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Ans:The Z scores here represent the LOD score that is the base 10 log of the ratio of the likelihoods of recombination and linkage.
A Z score of greater than or equal to 3 signifies the strong linkage, that of less than or equal to -2 indicates non-linkage, or recombination and the in-between values indicate insufficient data.
Hence,
a. Marker C and D are significantly linked to the trait allele anywhere within 0≤∪≤0.2. (See red boxes above)....
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