1) You cross true breeding male flies with smooth abdomens with true breeding female flies with cinnabar eyes and corrugated wings. The F1 offspring all appear phenotypically wildtype. You allow 20 of these F1 female flies to mate with 20 male flies that have smooth abdomens, corrugated wings, and cinnabar eyes. You observe the following offspring:

187 corrugated and cinnabar
164 smooth abdomen, corrugated and cinnabar
191 smooth abdomen
34 corrugated wings
109 cinnabar eyes
179 wild type
105 smooth abdomen and corrugated wings
31 smooth abdomen and cinnabar eyes

A) Determine the correct gene order and map the relative distances:
B) Determine the cross over interference for this region of the genome:
C) If we took 20 F1 phenotypically wildtype male flies from this cross and allowed them to mate with females that had smooth abdomens, corrugated wings, and cinnabar eyes, What Phenotypes would you expect in the progeny and in what ratios?

2) A) A female black cat and a male orange cat mate and have a litter of ten kittens. 4 male kittens have a black coat, 5 female kittens have a tortoiseshell coat (patches of orange and black) and 1 male has a tortoiseshell coat. Which kitten is the product of an unusual generic event? What type of genetic event occurred and in which parent? At which stage did it occur in this parent?
B) What genetic process causes the tortoiseshell coat pattern in cats? What is the name of the chromosomal configuration or structure associated with this process?

3) You discover a new allele in mice which results in an unusual curving of the tail. Mice with this phenotype are called “curly”. You cross a curly female mouse with a wildtype male mouse. You observe that all the male offspring are wildtype. Conversely, half of the females are curly and half of the females are wildtype. The number of male and female offspring are noticeably different.
A) Can you determine what chromosome this allele is on? Explain your reasoning:
B) What is the mode of inheritance of this allele? Be as precise as possible.

4) Two haploid mutant yeasts with mutations in the proline synthesis pathway were allowed to mate to form a diploid. Neither the haploids nor the resulting diploid were able to grow on media lacking proline. The diploids were placed in media that would cause them to sporulate and undergoing meiosis. Of the 400 tetrads analyzed 399 showed the expected phenotype, in that none of the four spores were able to grow on media lacking proline. However, one tetrad contained three spores that were unable to grow on media lacking proline, and one spore that could. What is your explanation for this unusual tetrad?

1) You cross true breeding male flies with smooth abdomens with tru...