• Explain the regulation of gene expression in eukaryotic cells.
• Discuss mechanisms by which gene expression may be altered. How do these alterations induce cancer-causing mutations in cell DNA?
• Explain how cancer is formed.
• Describe genetic changes found in cancer cells and how these changes lead to alterations in cell behavior.
• Determine whether proteome data can be utilized in genetic disorder diagnosis.
• Relate the Human Genome Project data to the analysis of cancer genes.
Format your paper consistent with APA guidelines.
These solutions may offer step-by-step problem-solving explanations or good writing examples that include modern styles of formatting and construction of bibliographies out of text citations and references. Students may use these solutions for personal skill-building and practice. Unethical use is strictly forbidden.Any mechanism by which transcription of RNA from the DNA template is controlled is part of the complex transcription regulation group of mechanisms. Regulation of transcription is a vital process to all organisms because not all information coded by the genome is needed in every moment in every single cell of our body. The phenotypic diversity of cells is the miraculous result of the tightly regulated and highly complex transcriptional regulation. Not all mechanisms of transcriptional regulation have been discovered or well-studied, but there are some well-established processes that have found their way in everyday practice as well. (Alberts, 2014)
One of the first described and most obvious modes of regulating gene expression is regulation at the level of chromatin. Namely, DNA is densely packed around histones and other proteins in order to fit into the nucleus and make a structure called chromatin. There are two forms of chromatin – euchromatin and heterochromatin. Heterochromatin includes DNA supercoiled around histones, and is therefore inaccessible for transcription machinery and transcription is not possible. On the other hand, euchromatin contains DNA that is less densely coiled and therefore could be straightened and accessed by transcription machinery. The control of supercoiling state of the DNA is an efficient way of preventing or allowing transcription to occur, even if all other conditions...
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