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Write a paper on topic: HEPATITIS C AND LIVER CANCER.

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Introduction:
Liver is one of the most important glands of the body associated with a plethora of functions. It not only is the largest gland of the body but also is associated with various metabolic functions like carbohydrate metabolism, protein metabolism, detoxification, lipid metabolism, haemopoiesis, and a host of other functions. In general, the functioning of liver is essential for the normal survival of the body. Liver cancer (hepatocellular carcinoma) is defined as a condition of undesirable hepatocyte growth of the liver, the stage termed as primary liver cancer, which later on gets distributed by metastasis to other parts of the body. There are different methods of ascertaining the stage of the cancer of liver. They are on based on parameters like size of the tumor, (TMN /tumor, node, metastasis staging system) or the size and position of the liver cancer(Barcelona Clinic liver cancer staging BCLC system), or the Child –Pugh System. (More about the stages of primary liver cancer, s.d).In order to describe the increasing frequency of liver cancer, Bosch et al,(2004) stated that
“Estimates from the year 2000 indicate that liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. The number of new cases is estimated to be 564,000 per year, including 398,000 in men and 166,000 in women.”
Of the different causes that lead to the development of Hepatocellular carcinoma, the chronic infection with either hepatitis B or hepatitis C leading to the cirrhosis of liver counts for the thirds most common reason of death by cancer and hepatocellular carcinoma itself is the fifth most common cancer
Hepatitis C has been documented to act through three ways, namely proliferation, apoptosis and chronic inflammation but recent researches indicate that production of a free radicals. It has also been declared that development of hepatocellular carcinoma is caused by immune reaction mediated hepatocyte injury even in absence of hepatitis C. Interestingly, holding hepatitis C responsible for liver cancer requires much more clear cause and effect explanation as far as the virus and host interaction are considered. (Oliveria Andrade et al., 2009).
The mechanism of hepatitis C causing cirrhosis of liver and infecting hepatocyte...

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