QuestionQuestion

Low-Dose Bisphenol-A Impairs Adipogenesis and Generates Dysfunctional 3T3-L1 Adipocytes
Part A:
The authors conclude that BPA exposure causes insulin resistance in adipocytes. Describe the experimental evidence in the paper which specifically demonstrates that insulin receptor signaling is impaired in adipocytes treated with BPA (you should cite the relevant figures in your answer).
Part B:
In this research article, the authors examined the effect of BPA on adipogenesis. As part of their study, they investigated how BPA treatment affects the protein expression levels of GLUT-4 and accumulation of neutral lipids (triacylglycerol) in cells. Describe the experimental findings reported by the authors related to GLUT-4 expression and cellular triacylglycerol accretion (you should cite the appropriate figures in your write-up) and explain their correlation.

Solution PreviewSolution Preview

This material may consist of step-by-step explanations on how to solve a problem or examples of proper writing, including the use of citations, references, bibliographies, and formatting. This material is made available for the sole purpose of studying and learning - misuse is strictly forbidden.

Part A
The authors conclude that BPA exposure causes insulin resistance in adipocytes. Describe the experimental evidence in the paper which specifically demonstrates that insulin receptor signaling is impaired in adipocytes treated with BPA (you should cite the relevant figures in your answer).
This is located in results section 3.2.. The figure is Figure 5. The evidence is in the fact that in normal (control) cells insulin is inducing the phosphorylation of cellular kinases ERK1/2 and PKB/AKT which transduce the initial signal into the cell leading to various final effects....
$25.00 for this solution

PayPal, G Pay, ApplePay, Amazon Pay, and all major credit cards accepted.

Find A Tutor

View available Molecular Biology Tutors

Get College Homework Help.

Are you sure you don't want to upload any files?

Fast tutor response requires as much info as possible.

Decision:
Upload a file
Continue without uploading

SUBMIT YOUR HOMEWORK
We couldn't find that subject.
Please select the best match from the list below.

We'll send you an email right away. If it's not in your inbox, check your spam folder.

  • 1
  • 2
  • 3
Live Chats