Question

For this assignment, you are instructed to select and read a research article appearing this calendar year in either the journal Analytical Chemistry or Analyst. After carefully perusing the article, you will write a 2 page summary (1.25 line spacing, 12 point font, Times New Roman) of the research, including the following details, in your own words:
(i) The title and reference to the work, including a hyperlink where the article can be found
(ii) an overall summary of the work performed and the results achieved
(iii) a description of the problem being solved and the approach used
(iv) a critical evaluation of the work, including any strengths and weaknesses you perceive
(v) a discussion of the novelty and significance of the work
(vi) a proposal for how the work could be expanded, improved upon, or extended
You may include drawings, pictures, and/or equations, as appropriate. These do not count against the 2-page limit.

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II. During the past two decades, various methods were applied to detect cannabinoids and their metabolites in human urine samples. Reported limits of detections (LOD) in those methods are often high enough to quantify cannabinoids in urine samples of active marijuana smokers. But those methods are not sensitive enough to detect cannabinoids in passive smokers who are exposed to second hand marijuana smoke (SHMS). In this article, Binnian Wei and other researchers from the Centers for Disease Control and Prevention, developed and validated a high sensitive analytical technique to quantify cannabinoids and their metabolites in urine from people exposed to SHMS. They used Ultra High Pressure Liquid Chromatography (UHPLC)-Electro Spray Ionization (ESI) coupled with Tandem Mass Spectroscopy (MS/MS) for this purpose. With this sensitive technique, they were able to achieve LODs ranging from 0.002 to 0.008 ng/mL for “free” (unconjugated forms) and 0.005 to 0.017 ng/mL for “total” (conjugated plus unconjugated forms). Their LODs are 10 to 100 times more sensitive than previously reported values in literature....

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