This material may consist of step-by-step explanations on how to solve a problem or examples of proper writing, including the use of citations, references, bibliographies, and formatting. This material is made available for the sole purpose of studying and learning - misuse is strictly forbidden.1. The pKa values for D (Aspartic Acid) and E (Glutamic Acid) are compared in table 4.1 to estimate the pKa values for the non-standard amino acid shown above. By observing the values for E and D in the table, the side chain for the aspartic acid is one carbon closer (-CH₂) compared to glutamic acid
(-CH₂-CH₂), which is further and the value changes from 3.86 to 4.07. Therefore, if an additional –CH₂ group is added to the structure, the pKa value should change to approximately 4.28....