Choose an enzyme involved in the metabolic pathways, and find an inhibitor to that enzyme included
(i) the name of the enzyme and chemical structure of both the natural substrate and the inhibitor,
(ii) whether the inhibitor is competitive, uncompetitive, or acts via another mechanism of inhibition,
(iii) the Ki of the inhibitor, and
(iv) a one page description of the proposed mechanism of inhibition which will require library research and should include description of where the inhibitor binds to the enzyme, whether the inhibitor is converted to a ‘suicide’ substrate.
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Answer: Glycolysis is the basic metabolic pathway for the extraction of energy from sugars in all the living cells and stores them in the form of adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NADH). The glucose is the substrate for glycolysis and pyruvate is the end product of this process. This whole glycolytic process is completed in 10 reactions which are catalyzed by 10 different enzymes. Out of these 10 reactions only three steps are regulatory steps and produce a large decrease in free energy, meaning they are dependent on the concentration of the step’s enzyme to proceed. These three regulatory steps are catalyzed by glucokinase or hexokinase, phosphofructokinase and pyruvate kinase enzymes....
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