Question 1 2 pts Which of the following is not a trans-acting ele...

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Question 1 2 pts Which of the following is not a trans-acting element in transcription? Sigma factor AP1 Cyclin D K-Ras TATA box Question 2 2 pts If the 5'->3' sequence of a segment of a RNA transcript reads UUCGGACU then which of the following is TRUE about the gene sequence? The template strand 5'-33 is TTCGGACT, and the coding strand 5'->3' is AAGCCTGA The template strand 5'->3' is AGTCCGAA, and the coding strand 5'->3' is TTCGGACT The template strand 5'->3' is AAGCCTGA, and the coding strand 5'->3' is TTCGGACT The template strand 5'->3' is TTCGGACT, and the coding strand 5'->3' is AGTCCGAA The template strand 5'-3' is AGTCCGAA, and the coding strand 5'->3' is TCAGGCTT Question 3 2 pts Lactose, but not glucose, is present in high concentrations in the culture medium for a wild type E. coli strain. Under these culture conditions, what proteins bind to the regulatory region of the Lac operon? Question 1 2 pts Which of the following is not a trans-acting element in transcription? Sigma factor AP1 Cyclin D K-Ras TATA box Question 2 2 pts If the 5'->3' sequence of a segment of a RNA transcript reads UUCGGACU then which of the following is TRUE about the gene sequence? The template strand 5'->3' is TTCGGACT, and the coding strand 5'->3' is AAGCCTGA The template strand 5'->3' is AGTCCGAA, and the coding strand 5'->3' is TTCGGACT The template strand 5'->3' is AAGCCTGA, and the coding strand 5'->3' is TTCGGACT The template strand 5'->3' is TTCGGACT, and the coding strand 5'->3' is AGTCCGAA The template strand 5'-3' is AGTCCGAA, and the coding strand 5'->3' is TCAGGCTT Question 3 2 pts Lactose, but not glucose, is present in high concentrations in the culture medium for a wild type E. coli strain. Under these culture conditions, what proteins bind to the regulatory region of the Lac operon? RNA polymerase cAMP receptor protein (CRP) and RNA polymerase lac repressor and RNA polymerase Question 4 2 pts Which of the following is NOT part of a nucleosome core histone H2A 2 pla histone H2B histone H3 histone H4 All of the above are within a nucleosome core Question 5 2 pts Enzymes involved in the conversion H3K9ac to H3K9me1 are and . histone acetyltransferase (HAT); histone methyltransferase (HMT) 2 histone deacetylase (HDAC); DNA methyltransferase (DNMT) histone deacetylase (HDAC); histone methyltransferase (HMT) histone actyltransferase; DNA methyltransferase (DNMT) None of the above Question 6 2 pts Which of the following in NOT an effect of histone acetylation? The positive charges on lysines are neutralized. Conversion of the beads on a string to the 30 nM fiber. DNA binding to the nucleosomes is weakened Recruitment of SWI/SNF Disruption of electrostatic interactions between neighboring nucleosomes Question 7 2 pts The function of the guanylyItransferase activity of capping enzyme is to catalyze formation of the linkage in the 5' cap of structure of a eukaryotic mRNA. 5',5' triphosphate 5',5' diphosphate 3',5' triphosphate 3',5' monophosphate 5',3' triphosphate Question 8 2 pts During assembly of a spliceosome, the snRNA molecule in U1 snRNP anneals to the and the snRNA in U2 snRNP binds at the 5. splice site; branch point 3' splice site; branch point branch point; 5' splice site branch point; 3' splice site 5' splice site; 3' splice site Question 9 2 pts Use the table to determine the primary amino acid sequence of the polypeptide encoded in the following eukaryotic mRNA molecule. 5'-AUGGCUGAAAGAACUUAUUCUACGAAAGAAUCGUGAACAGCA-3' Second Position U C A G code Amio Acid code Amio Acid code Amo Acid code Amo Acid UUU UCU UAU UGU U phe tyr cys UUC U UCC UAC UGC C ser UUA UCA UAA STOP UGA STOP A leu UUG UCG UAG STOP UGG trp G CUU CCU CAU CGU U his CUC C CCC CAC CGC C leu pro CUA arg CCA CAA CGA A gin CUG CCG CAG CGG G AUU ACU AAU AGU U asn ile ser AUC A ACC AAC AGC C thr AUA ACA AAA AGA A AUG met lys ACG AAG arg AGG G GUU GCU GAU GGU U GUC GCC asp G GAC val GGC C ala GUA GCA gly GAA GGA A GUG GCG glu GAG GGG G Met- Lys-Arg-Asp-His-Gly-Arg-Glu-Asp-Leu-Ser-Met-Glu-His-Lys-Gly-Val-Trp-Ser-Met-Thr Met-Arg-Asp-His-Gly-Arg-Glu-Asp-Leu-Ser-Met-Glu-His-Lys-Gly-Val-Trp-Ser-Met-Th Met-Met-Ala-Glu-Arg-Thr-Tyr-Leu-Trp-Ser-Thr-Lys-Glu-Ser-Gly-Val Met-Ala-Glu-Arg-Thr-Tyr-Ser-Thr-Lys-Glu-Ser Met-Glu-His-Lys-Gly-Val-Trp-Ser-Met-Thr Question 10 2 pts A mutation results in a single-base substitution in a codon, GAG-+AAG. This mutation would be considered a/an mutation. Second Position U C A G code Amro Acid code Amo Acid code Amio Acid code Amio Acid UUU UCU phe UAU UGU U UUC U UCC tyr UAC cys UGC ser C UUA UCA leu UAA STOP UGA STOP A UUG UCG UAG STOP UGG trp G CUU CCU CAU CGU U his CUC C CCC leu CAC CGC C pro CUA CCA CAA arg CGA A CUG gIn CCG CAG CGG G AUU ACU AAU AGU U AUC ile asn ACC ser A AAC AGC thr C AUA ACA AAA AGA A AUG met ACG lys AAG arg AGG G GUU GCU GAU GGU U GUC GCC asp G val GAC ala GGC C GUA GCA gly GAA GGA A GUG GCG glu GAG GGG G in-frame missense nonsense silent None of the above Question 11 2p Which of the following statements is TRUE? The ribosome has aminoacyl transferase activity. Elongation factors (EF) interact with the 50S ribosome. In prokaryotes initiator tRNA is charged with N-formylmethionine, but eukaryotic initiator tRNA is charged with methionine. Aminoacyl-tRNA synthetases bind to the invariant modified bases in a tRNA to ensure that it is charged with the correct amino acid. None of the above. Question 12 An inactive form of an enzyme that must undergo proteolysis to achieve an active conformation is called a signal sequence zymogen holoenzyme glycoprotein None of the above Question 13 2 pts Which of the following is NOT a function associated with signal recognition particle (SRP)? arresting synthesis of a nascent membrane protein translocation of a nascent secreted protein into the lumen of the endoplasmic reticulum binding the signal sequence of a nascent polypeptide chain docking onto the SRP receptor on the endoplasmic reticulum All of the above are functions of SRP. Question 14 2 pts Which of the following is the "E2" enzyme that donates a ubiquitin molecule to lysines on specific target proteins? ubiquitin activating enzyme ubiquitin ligase proteosome ubiquitin synthetase ubiquitin conjugating enzyme 6/2 IF-2 with charged initiator tRNA 50S ribosomal subunit EF-Tu with charged tRNA EF-G Question 18 2 pts The type of damage shown in figure (a) below is generally repaired by . O O CH3 3 H,C 3 H-N N H O N N P P P (a) (b) 2 pts Base excision repair (BER) Methylguanine methyltransferase Nucleotide excision repair (NER) Flap endonuclease Mismatch repair 2 pts Question 19 Which of the following eukaryotic RNA polymerases is responsible for transcription of tRNA transcripts? RNA pol I RNA Pol Il RNA Pol III RNA Pol IV RNA Pol V Question 20 2 pts Four structural domains of tRNA transcripts include the T loop, the D loop, the anticodon loop, and the amino acid group. acceptor stem. DNA domain. Y loop. Psi () stem. Question 21 2 pts The methyl group used to methylate the 5' guanine cap is donated directly by guanylyl transferase. methionine. S-adenosylmethionine. co-enzyme A. cytosine. 2 pts Question 22 Spliceosomes are complexes of proteins and tRNAs. DNA. rRNA. snRNA. All of the above. Question 23 2 pts The genetic code is described as because more than one codon can encode for a specific amino acid. multifunctional degenerate mature deteriorate compound Question 24 2 pts The region of a mature mRNA transcript that encodes for the primary structure of a protein is termed the pix 3' untranslated region (3' UTR) 5' untranslated region (5' UTR) Open reading frame (ORF) promoter translational stop codon 2 pts Question 25 Lysine residues present within the histone "tails" of nucleosomes can be subjected to mono-, di-, and tri- . phosphorylation methylation carboxylation acetylation ubiquitination Question 26 2 pts During meiotic recombination, a structure where a maternal DNA strand is base paired with a paternal DNA strand is termed . a DNA recombination joint gene conversion mismatch repair heteroduplex DNA synaptonemal complex Question 27 2 pts Oxidation of cytosine to is a commonly encountered form of DNA damage. thymine uracil adenine guanine None of the above 2 pts Question 28 Cisplatin exposure DIRECTLY results in all of the following types of damage EXCEPT DNA strand breaks. DNA interstrand crossinks DNA intrastrand crossinks protein/DNA crosslinks Question 29 2 pts lonizing radiation exposure directly results in DNA double strand breaks base oxidation deoxyribose oxidation DNA single strand breaks All of the above Question 30 2 pts During translation in eukaryotes mRNA is translated in a 3' to 5' direction. base pairing between tRNA and mRNA occurs. polymerization occurs in a carboxy-terminal to amino-terminal direction. the mRNA remains within the nucleus. the Shine-Dalgarno sequence within the mRNA is critical for initiation. 2 pts Question 31 DNA damage repair by non-homologous end joining (NHEJ) is necessary for mismatch repair. is responsible for the repair of thymine dimers. is a saturable process. can result in the loss of genetic information. None of the above. Question 32 2 pts The genetic disorder Xeroderma pigmentosum is caused by defects in direct DNA repair. base excision repair (BER). mismatch repair (MMR). nucleotide excision repair (NER). DNA double strand break repair. Question 33 2 pts is critical for the process of gene conversion. Peptidyltransferase Aminoacyl tRNA synthetase Mismatch repair Poly-A binding protein RNA splicing 2 pts D Question 34 Retrotransposons differ from DNA transposons because they 414 require specific telomerase structures. occur within heterochromatin only. require the synthesis of an RNA intermediate. contain no structural genes. do not encode reverse transcriptase. Question 35 2 pts Both c-Jun and c-Fos are cyclin-dependent kinases. peptide hormone growth factors. inhibitors of cyclin D. early response genes. stoichiometric inhibitors of p27. Question 36 2 pts Which of the following is synthesized by the stroma of the mammary gland? IGF1 Receptor (IGF-1R) Estrogen Progesterone IGF1 Growth hormone (GH) Question 37 2 pts The process of protein synthesis is called . replication transcription recombination translation reverse transcription Question 38 2 pts In prokaryotes, an operator sequence would be located a promoter to block RNA polymerase binding, or of a promoter to block the promoter clearage step in translation. upstream; downstream downstream: within upstream; within downstream; upstream within; downstream Question 39 2 pts The function of transcription factor TFIID in the eukaryotic transcription preinitiation complex is to . bind RNA polymerase Il and escort it to the promoter eject nucleosomes from the transcription start site recognize and bind to cis-acting promoter elements provide the DNA helicase activity for transcription recruit histone acetyltransferase to open chromatin structure Question 40 2 pts A is a site within a nucleus where RNA is both synthesized and processed into a mature mRNA. spliceosome ribosome transcription factory transcriptome chromosome Question 41 2 pts Which of the following cyclins is primarily responsible for cell advance into mitosis? Cyclin A Cyclin B Cyclin C Cyclin D Cyclin E 2 pts Question 42 Following strand invasion and ligation, the recombination joint is free to move along the synapsed sister chromatids, this is referred to as . resolution patch recombinants branch migration gene conversion polymorphism Question 43 2 pts Which of the following events is LEAST associated with cell cycle advance through the restriction point? Dissociation of the Rb/E2F complex Continued AP1 transcription factor activity Overcoming CIP protein (ie, p21/27) inhibitory capacity Activation of the wee-1 kinase Expression of delayed response genes Question 44 2 pts During which of the following transpositional events is a cointegrate is formed? Simple transposition Ty1 element retrotransposition Replicative transposition LINE element integration Nonautonomous retrotransposition Question 45 2 pts Both SHC and GRB2 contain that bind to the cytoplasmic domain of phosphorylated IGF-1R. GTPase domains GTP-exchange factors (GEFs) SH2 domains GTPase activators RAF interaction domains Question 46 2 pts Which of the following events is NOT attributable to MPF activity? Formation of the mitotic spindle Condensation of chromosomes Activation of anaphase-promoting complex Dissociation of the Rb/E2F complex Depolymerization of the nuclear lamina Question 47 2 pts Lack of nutritional support in a growing tumor will result in tumor suppressor expression oncogene ubiquitination metastasis a necrotic center within tumor mass activation of the epithelial to mesenchymal transition Question 48 2 pts Formation of the Philadelphia Chromosome DIRECTLY results in deletion of the p53 tumor suppressor gene duplication of the C-Myc oncogene inactivation of Rb overexpression of p16 abnormal activity of c-Abl Question 49 2 pts Which of the following therapeutics is used to inhibit tumor angiogenesis? Gleevec Mercaptopurine Avastin Taxol Thymidylate synthase Question 50 2 pts DNA glycosylases are enzymes that function in DNA strand break repair repair of cyclobutane pyrimidine dimers (thymine dimers) repair of intra-strand DNA crosslinks base excision repair (BER) mismatch repair (MMR)

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1 E
2 A
3 D
4 E
5 C
6 B
7 A
8 A...
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