Analysis of protein structure/function Choose at least one rece...

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Analysis of protein structure/function

Choose at least one recent paper investigating a topic in protein structure and function with a protein of interest specifically from mouse (mus musculus) with a polypeptide length of at least 300 amino acids (Note that the RAR/RXR proteins – including all subtypes – are not permitted as they were used in the assignment demonstration). Use only primary literature; no reviews. Use the chosen paper(s) as a guide to carry out an original analysis on how the protein structure influences and determines its function(s). In the report provide background information about your protein and discuss the rationale for the analysis you have performed. Use Deep View to illustrate your analysis and conclusions.


Examples of a potential original analysis:

1.Hypothesize the effect on function of changes in primary amino acid sequence, in the context of disease or in the process of developing novel functions.
2. Modeling of the potential tertiary structure of a protein based on the known structure of similar proteins as for example modeling the structure of an alternative splice variant protein based on the structure of the wild type protein.
3. Analysis of the function of conserved amino acids in a family of homologous proteins.

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