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Answer the following questions:

1. If 1000 milliliters of a certain solution contain 30 milligrams of a dye, (a) what is the volume of the tenth aliquot and (b) how many milligrams of the dye will the tenth aliquot contain?
2. A prescription balance has a sensitivity requirement of 0.006 gram. Explain how you would weigh 0.012 gram of atropine sulfate with an error not greater than 5%, using lactose as the diluent.
3. A torsion prescription balance has sensitivity requirement of 4 milligrams. Explain how you would weigh 5 milligrams of hydromorphone hydrochloride with an error not greater than 5%. Use lactose as the diluent.
4. The sensitivity requirement of a prescription balance is 1/16 grain. Explain how you would weigh 1/10 grain of atropine sulfate with an error not greater than 5%. Use milk sugar as the diluent.
5. A prescription balance has a sensitivity requirement of 6.5 milligrams. Explain how you would weigh 20 milligrams of a substance with an error not greater than 2%.
6. A prescription balance has a sensitivity requirement of 1/6 grain. Explain how you would weigh 1 grain of a substance with an error not greater than 5%.
7. A torsion prescription balance has a sensitivity requirement of 0.004 gram. Explain how you would weigh 0.008 gram of a substance with an error not greater than 5%.
8. A prescription balance has a sensitivity requirement of 1/8 grain. Explain how you would weigh ¾ grain of a substance with an error not greater than 5%.
9. A formula calls for 0.6 milliliter of a coloring solution. Using a 10-milliliter graduate calibrated from 2 to 10 milliliters in units of 1 milliliter, how could you obtain the desired quantity of the coloring solution by the aliquot method? Use water as the diluent.
10. A pharmaceutical formula calls for 0.4 ml. of the surfactant polysorbate 80. Using water as the diluent and a 10 milliliter graduate calibrated in units of 1 milliliter, how could you obtain the desired quantity of polysorbate 80?
11. Using a 10 milliliter grade calibrated in units of 1 milliliter, explain how you would measure 1.25 milliliters of a dye solution by the aliquot method. Use water as the diluent.
12. The formula for 100 ml. of Pentobarbital Sodium Elixir calls for 0.75 ml. of orange oil. Using alcohol as a diluent and a 10 milliliter graduate calibrated in units of 1 milliliter, how could you obtain the desired quantity of orange oil?

13. Rx
Aspirin 15 g.
Pyrilamine Maleate 500 mg.
Chlorpheniramine Maleate 50 mg.
Lactose q.s.
Mix and make 50 capsules
Sig. One capsule t.i.d.
Using a prescription balance having a sensitivity requirement of 6 mg., explain how you would obtain the required amount of chlorpheniramine maleate with an error not greater than 5%.

14. Rx
Phenobarbital 400 mg.
Ergotamine Tartrate 6 mg.
Belladonna Extract 160 mg.
Lactose q.s.
Mix and make 20 capsules
Sig. One capsule as directed
Using a prescription balance having a sensitivity requirement of 6 mg., explain how you would obtain the required amount of ergotamine tartrate with an error not greater than 4%

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1. If 1000 milliliters of a certain solution contain 30 milligrams of a dye, (a) what is the volume of the tenth aliquot and (b) how many milligrams of the dye will the tenth aliquot
contain?
Ans:
1000 mL solution contains 30 mg of dye
So concentration will be
= 30/1000 mg/mL
= 0.003 mg/mL

(a) And its 10th aliquot will have volume is (divide whole volume in 10 parts)
=1000/10 mL
= 100mL

(b) 10th aliquot (100 mL) will have concentration of dye
= concentration in mg/mL X 100mL
= 0.003X100
=0.3 mg

2. A prescription balance has a sensitivity requirement of 0.006 gram. Explain how you would weigh 0.012 gram of atropine sulfate with an error not greater than 5%, using lactose as the diluent.
Ans:
(i) Smallest quantity may be weighed
= 100% x Sensitivity requirement/acceptable error (%)
= 100% x 0.006 g / 5%
= 0.12 g

(ii) 0.012 g of atropine sulfate needed which is ten time less than smallest quantity to be weighed
Multiplying factor 10
=0.12 g of drug
And 0.12 x 10 will be drug + diluents
=1.2 g

(iii) Prepare a mixture of total amount 1.2 g
Include 0.12 g of drug and 1.08 g diluents

(iv) Now mixture of 1.2 g is divided in 10 aliquot
Each part will have =0.012 g drug (Atropine sulfate) and 0.108 g of diluents (Lactose)...
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