Question

During an experiment, you administered 10 mg of a substance to a mouse intravenously. At several intervals, you collected blood samples and analyzed them for the concentration of the chemical. You obtained the following results: 10 min, 850 mcg/ml; 30 min, 630 mcg/ml; 60 min, 395 mcg/ml; and 120 min, 160 mcg/ml.

Does this elimination appear to reflect a one-compartment or two-compartment model?
What is the elimination half-life?
Can you calculate a volume of distribution for this chemical? If so, what is it? If not, what additional information do you need?
Can you calculate a clearance for this chemical? If so, what is it? If not, what additional information do you need?

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Does this elimination appear to reflect a one-compartment or two-compartment model?
Ans: The rapid intravenous injection is commonly described by one compartment model where drug directly leave from the body after administration. Hence this is an example of one compartment model.

What is the elimination half-life?
Ans: Elimination half-life is the period of time required for the concentration or amount of drug in the body to be reduced or eliminated by one-half from the initial concentration....

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