Subject Chemistry Pharmaceutical Chemistry

Question

Polymorphisms in xenobiotic metabolizing enzymes are important contributors to differences among individuals in response to toxicants. Pick a xenobiotic enzyme for which polymorphism exists, identify the forms that exist and how they are distributed among subgroups in the population (ethnicity, geographical distribution, etc.), and how they substantially influence the toxicity of one or more drugs or chemicals. Provide at least one specific example.

Solution Preview

This material may consist of step-by-step explanations on how to solve a problem or examples of proper writing, including the use of citations, references, bibliographies, and formatting. This material is made available for the sole purpose of studying and learning - misuse is strictly forbidden.

Polymorphism is characterized as two or more inherited phenotypes which derived from the same gene(s). Various xenobiotic metabolizing enzymes show the polymorphisms and have individual and inter-ethnic differences. Some studies reported the variation alleles of the human CYP1A1, CYP2E1 has implications in adenocarcinoma and lung cancer. Cytochrome P450 superfamily is most studied on drug metabolism and has a lot of individual variability.

The interest in CYP1A subfamily increased by a study reported in 1973 which correlated the level of CYP1A1 inducibility in cigarette smokers with individual susceptibility to lung cancer. Its polymorphism with difference in gene has also been identified, and which found to influence lung cancer risk amongst Japanese cigarette smokers, whereas in other ethnic groups it does not appear to influence lung cancer....

This is only a preview of the solution. Please use the purchase button to see the entire solution

Assisting Tutor

Related Homework Solutions

Pharmaceutical Chemistry Questions
Homework Solution
$63.00
Chemistry
Pharmacy
Dye
Prescription Balance
Lactose
Atropine Sulfate
Hydromorphone Hydrochloride
Mixtures
Aliquot
Substances
Drugs
Color Solution
Surfactant Polysorbate
Orange Oil
Experiments
Analysis
Laboratory
A Study on Drug Pharmacokinetics
Homework Solution
$13.00
Chemistry
Pharmaceutical Chemistry
Pharmacokinetics
Drug
Study
Partment Model
Elimination Rate
Intravenous Dose
Pharmaceutical Chemistry Experiment
Homework Solution
$25.00
Chemistry
Pharmacy
Biology
Experiments
Substances
Mouse
Blood Samples
Analysis
Chemicals
Elimination
One-Compartment Model
Two-Compartment Model
Volume of Distribution
Information
Results
Semi-Log Plots
Diagrams
Observations
Routes of Metabolism
Homework Solution
$18.00
Medicine
Chemistry
Metabolism
Fexofenadine
Cortisone
Cofactors
Urine
Reactions
Enzymes
Reductase
Cortolone
Oxidation
Reduction
Azacyclonol
Dehydrogenase
Get help from a qualified tutor
Live Chats