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From the above dissolution profiles of three different formulations of same drug X, manufactured by wet granulation method and by applying different compression force, it was observed that the rate of release of drug from the tablet, significantly depends on the force applied for its compression.
In Formulation A, the amount of drug was released in an linear fashion i.e. 10, 25, 45, 60, 85, 110, 140, 170 and 200 mg with respect to time i.e. 5, 10, 15, 20, 25, 30, 35, 40 and 45 minutes, which is represented in graph-1 also.
In Formulation B, first 50 mg of drug was released within 5 minutes, then 80, 100, 120, 140, 180, 200 mg at time 10, 15, 20, 25, 30, 35 minutes respectively. At 35 minutes complete drug is released from the tablet in formulation B. This indicates that the release rate of drug in Formulation B did not follow linearity. This is because...