Propose a method to develop your engineered tissue (2 pages).
For each of the three aims you have developed, outline the necessary experiments to examine your proposed hypothesis; suggest alternatives and markers of success.
Submissions should have 1.0 line spacing, 10 point Arial font, 0.75 inch margins on all sides, bold type for major section headings, and any widely accepted reference style. All references must come from peer reviewed journals.
To address these hypotheses, the following specific aims are proposed:
Investigate implant toxicity: Parylene-C film is an amenable scaffold for hESC-RPE while demonstrating biocompatibility with hESC-RPE, choroidal, and retinal tissues.
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Initial experimentation with inherited RPE dystrophy in rats has indicated that the degeneration of the photoreceptors can be prevented long with ophthalmic functionality can be restored. Similar transplantation human eyes also hold promise for treatment. (Alexander et al, 2015). Dry AMD is devoid of any treatment, and current research is focussed on the use of RPE implants obtained from either human embryonic or...