Subject Engineering Engineering - Other


Research Design and Aims
Propose a method to develop your engineered tissue (2 pages).
For each of the three aims you have developed, outline the necessary experiments to examine your proposed hypothesis; suggest alternatives and markers of success.
Submissions should have 1.0 line spacing, 10 point Arial font, 0.75 inch margins on all sides, bold type for major section headings, and any widely accepted reference style. All references must come from peer reviewed journals.
To address these hypotheses, the following specific aims are proposed:
Investigate implant toxicity: Parylene-C film is an amenable scaffold for hESC-RPE while demonstrating biocompatibility with hESC-RPE, choroidal, and retinal tissues.

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The primary discrepancy in the function of the retinal layers begins in the RPE in cases of the age predated macular degeneration (AMD) leading to visual impairment. Additionally, the development of drusen formation by aggregate formation leaving behind a geographic atrophy. According to Nagineni et al. (2012), the primary pathological implications occur in the human retinal pigment epithelial cell (hRPE) layer and the choroidal tissues in AMD where the VEGF (Vascular endothelial growth factor) has been considered as the principal performer in choroidal neovascularization or (CNV).To provide treatment for the wet AMD the aspect of regulation of VEGF has been the mainstay of research and some companies had developed anti –VEGF treatment options. The concept behind the use such drugs was the inhibition of the VEGF but each of the medications required monthly or semi-monthly administration and also need an early diagnosis of the problem to render a useful result. It is found that the retinal pigment epithelial cells do not require synaptic connections like other cells of the retina and are easily culture able in the laboratory.
Initial experimentation with inherited RPE dystrophy in rats has indicated that the degeneration of the photoreceptors can be prevented long with ophthalmic functionality can be restored. Similar transplantation human eyes also hold promise for treatment. (Alexander et al, 2015). Dry AMD is devoid of any treatment, and current research is focussed on the use of RPE implants obtained from either human embryonic or...

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