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TOPIC: ion channel is KCa3

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Ion Channel KCa3

Specific aims
KCa3 ion channel contributes to various processes in malignant progression and cancerogenesis (Mohr et al., 2019a). Consequently, the channel has increasingly become a centerstage in its involvement in several cancer entities, one of them being breast cancer. The potential of KCa3 as an anti-tumor target and its role in breast cancer in which the channel expresses itself based on the cell cycle (Mohr et al., 2019a). The most recent studies such as that by Steudel et al. (2017) demonstrate that the pharmacological or genetic inhibition of the KCa3 interferes with the progression of the breast tumor vitriol in an orthotopic breast cancer mouse model. Other studies...
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