Subject Medicine and Nursing Pathology


Choose a chronic disease or condition and select a particular one for your Literature Review. A chronic disease is a long lasting condition that can typically be treated, but not necessarily cured (for example, atherosclerosis, arthritis, diabetes, and cancer). Find at least four recent (less than 3 years old), peer reviewed, primary research articles that concisely explain the pathophysiology of your topic. Annotated bibliography. APA style.
You may use more than the minimum number of sources, as needed, to support your Literature Review paper, but your Annotated Bibliography should rely mainly on primary research. You may also utilize a high quality review article or meta-analysis, but note that a review article is secondary, so does not count as one of the required four primary studies. If you use any secondary sources, make sure they are of good quality, from a scholarly source.
Your Instructor uses the Module 3 Annotated Bibliography Rubric to grade this Assignment.
Submit the Annotated Bibliography, to include:
•Title page
•Concise description of the focus
•Sources: Four recent (less than 3 years old), primary, peer-reviewed research articles that support the topic of your paper. Beyond the minimum four primary research articles, you may add additional, high quality secondary literature (reviews or meta-analyses), and you may use websites—if from a scholarly and relevant source (e.g., CDC, NCHS, etc.). Note: Your sources must follow APA formatting.
•Annotation: For each research article, include the study aim, the methods used, and the findings. For each non-research source, provide a concise description of the relevant key points addressed in the source. Include in the annotation a brief description of how you plan to use each source (e.g., provides statistics for the problem, etc.)

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There have been a number of manuscripts reporting on the association of atherosclerosis with low levels of high density lipoproteins (HDL), high low-density lipoprotein (LDL) uptake, high fructose intake in diet and a causal C5a complement activation.
In order to further investigate the pathophysiology of atherosclerosis, papers were reviewed through 2013 using the NIH PubMed Literature Search System. Inclusion criteria were that manuscripts 1) be primary peer-review research article; 2) concisely explained, or investigated, the pathophysiology of atherosclerosis; 3) be published in English.
Low serum HDL concentration resulted to be strongly correlated with enhanced inflammation, endothelial activation and oxidative stress, thus inducing atherosclerosis. Fructose was found responsible in promoting atherosclerosis by inducing transcription of mRNA for tissue factor (TF)....

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