Question

Answer the following questions based on an overview of genotoxic and non-genotoxic effects of carcinogens:

1.What is TCDD?

2. How is TCDD generated?

3. To what receptor does TCDD bind?

4. What other compound binds to the same receptor?

5. Name three genes involved in the generation of cancer whose expression is increased by TCDD. Write the function of these genes.

6. Name three genes involved in the generation of cancer whose expression is reduced by TCDD. Write the function of these genes.

7. Why is TCDD considered a non-genotoxic carcinogen?

8. Explain why the (+)-anti-BPDE has the highest intrinsic genotoxic and carcinogenic potency.

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1. What is TCDD?
Ans: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a polychlorinated dibenzo-p-dioxin. TCDD is a colorless solid compound having no specific odor. TCDD one of the most potent carcinogenic among its series of compounds, i.e., Polychlorinated dibenzodioxin. It causes cancer, and this has been proved through various scientific evidence done of a human.

2. How is TCDD generated?
Ans: TCDD is formed as a byproduct during the synthesis as well as burning of organic compounds. Such as during the synthesis of chlorophenols, herbicides such as chlorophenoxy acid as a side product TCDD is synthesized. Also during the burning of organic compounds, it is formed along with other polychlorinated dibenzodioxin and dibenzofurans. It has never synthesized commercially....

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