Pharmacokinetic Questions

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1. For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.
The infusion rate needed to achieve the 35mg/L concentration can be determined as follows...

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