Develop a drug carrier by using Nanoparticles/Liposomes producing growth hormone. What are the shortcoming(disadvantages) of this system compared to the injection of growth hormone directly?

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Growth hormone therapy is required for the treatment of growth hormone deficiency (in children and in adults), Prader-Willi and Turner syndrome, chronic renal insufficiency, idiopathic short stature in children, AIDS-related wasting and fat accumulation which is associated with lipodystrophy in adults.
There are various side effects associated with growth hormone therapy which includes headache, nausea, vomiting, visual problems, peripheral edema, myalgia, arthralgia, hypothyroidism, antibody formation, paraesthesia, and reactions at the injection site.
Growth hormone is usually injected subcutaneously on a daily basis, and this is considered to impact upon patient compliance. To overcome the compliance issue and improve dosing accuracy, extended-release growth hormones preparations are developed. The extended-release growth hormone preparation can be prepared by using nanoparticles or liposomes as a drug carrier system....

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