Subject Medicine and Nursing Human Physiology

Question

1.   Is the clinical scenario most consistent with a coagulopathy or platelet dysfunction? You may simply list your answer below using a bullet point format. This does not have to be in a complete sentence.

2.    What data in the clinical scenario supports your diagnosis? You may simply list your answers below using bullet point format. This does not have to be in a complete sentence.

3.    Which disorder (diagnosis) is the most likely cause of this patient’s bleeding dysfunction? You may simply list your answer below using a bullet point format. This does not have to be in a complete sentence.

4.    Describe the key pathophysiologic concepts of the diagnosis in question 1. To answer this question completely, you must answer all of the sub-questions below using complete sentences. Each sub-question may be answered in 1-6 sentences.
a. Explain why the PTT is abnormal and the PT is normal?
b. In which gender is this disorder more common and why?
c. How do the clinical manifestations in a patient who is bleeding secondary to a platelet dysfunction/disorder differ from one who is bleeding secondary to a coagulopathy?
d.    Which factor deficiency is the most likely culprit for this child's disorder?

5. For what actual or potential complications related to the diagnosis in question 3 does he need to be monitored? You may simply list your answer below using a bullet point format. This does not have to be in a complete sentence.

Solution Preview

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1. Is the clinical scenario most consistent with a coagulopathy or platelet dysfunction?
The clinical scenario is most consistent with platelet dysfunction specifically referred to as Glanzmann’s thrombosthenia.

2. What data in the clinical scenario supports your diagnosis?
The diagnosis of Glanzmann’s thrombosthenia is supported by the clinical scenario data as follows;
The clinical condition involves a 20 months child. A key symptom of the diagnosed condition is mucocutaneous bleeding occurring during the neonatal period....

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